SV2017005384A - Compuestos aminopirimidinilo - Google Patents
Compuestos aminopirimidiniloInfo
- Publication number
- SV2017005384A SV2017005384A SV2017005384A SV2017005384A SV2017005384A SV 2017005384 A SV2017005384 A SV 2017005384A SV 2017005384 A SV2017005384 A SV 2017005384A SV 2017005384 A SV2017005384 A SV 2017005384A SV 2017005384 A SV2017005384 A SV 2017005384A
- Authority
- SV
- El Salvador
- Prior art keywords
- rent
- group
- hydrogen
- replaced
- heteroarilo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 6
- -1 AMINO Chemical class 0.000 abstract 3
- 101100275473 Caenorhabditis elegans ctc-3 gene Proteins 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201462039969P | 2014-08-21 | 2014-08-21 |
Publications (1)
Publication Number | Publication Date |
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SV2017005384A true SV2017005384A (es) | 2017-07-10 |
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SV2017005384A SV2017005384A (es) | 2014-08-21 | 2017-02-16 | Compuestos aminopirimidinilo |
Country Status (48)
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2336117A1 (en) | 2005-05-26 | 2011-06-22 | Neuron Systems, Inc | Heterocyclic compounds for treating retinal diseases |
WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
HK1217439A1 (zh) | 2013-01-23 | 2017-01-13 | Aldeyra Therapeutics, Inc. | 與毒性醛相關的疾病和治療 |
JP6577958B2 (ja) | 2014-04-11 | 2019-09-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | スピロ[3H−インドール−3,2’−ピロリジン]−2(1H)−オン誘導体およびMDM2−p53阻害剤としてのそれらの使用 |
US10576064B2 (en) | 2014-07-03 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors |
NO2721710T3 (en]) | 2014-08-21 | 2018-03-31 | ||
HUE046057T2 (hu) | 2014-08-21 | 2020-02-28 | Boehringer Ingelheim Int | Új spiro[3H-indol-3,2'-pirrolidin]-2(1H)-on vegyületek és származékok, mint MDM2-P53-inhibitorok |
EP4400106A1 (en) | 2015-08-21 | 2024-07-17 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
EP3347097B1 (en) | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
PE20181205A1 (es) | 2015-10-09 | 2018-07-23 | Boehringer Ingelheim Int | Nuevos compuestos de espiro[3h-indol-3,2'-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53 |
CA3020506A1 (en) * | 2016-04-28 | 2017-11-02 | Theravance Biopharma R&D Ip, Llc | Pyrimidine compounds as jak kinase inhibitors |
AU2017264697A1 (en) | 2016-05-09 | 2018-11-22 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
US10111882B2 (en) | 2016-09-14 | 2018-10-30 | Gilead Sciences, Inc. | SYK inhibitors |
TW201822764A (zh) | 2016-09-14 | 2018-07-01 | 美商基利科學股份有限公司 | Syk抑制劑 |
EP3848370B1 (en) | 2016-10-14 | 2025-05-07 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
MA47106A (fr) | 2016-12-21 | 2019-10-30 | Amgen Inc | Formulations d'anticorps anti-tnf alpha |
CN110431130A (zh) | 2017-03-16 | 2019-11-08 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
WO2018195471A1 (en) | 2017-04-21 | 2018-10-25 | Gilead Sciences, Inc. | Syk inhibitors in combination with hypomethylating agents |
CN108864057B (zh) * | 2017-05-16 | 2020-03-31 | 山东大学 | 含有4-氨基吡唑结构的jak与hdac双靶点抑制剂及其制备方法和应用 |
CN109422753B (zh) * | 2017-09-03 | 2021-12-31 | 上海美志医药科技有限公司 | 一类具有抑制并降解酪氨酸蛋白激酶jak1或jak2活性的化合物 |
MX2020003425A (es) | 2017-10-10 | 2020-07-29 | Aldeyra Therapeutics Inc | Tratamiento de trastornos inflamatorios. |
CN111247142B (zh) * | 2017-10-27 | 2022-12-02 | 施万生物制药研发Ip有限责任公司 | 作为jak激酶抑制剂的嘧啶化合物 |
JP7254076B2 (ja) | 2017-11-19 | 2023-04-07 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 置換ヘテロアリール化合物及び使用方法 |
AU2019216522A1 (en) | 2018-02-05 | 2020-08-27 | Alkermes, Inc. | Compounds for the treatment of pain |
CA3106470A1 (en) | 2018-07-17 | 2020-01-23 | Nippon Chemiphar Co., Ltd. | T-type calcium channel blocker |
AU2019319740A1 (en) | 2018-08-06 | 2021-03-25 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
WO2020068846A1 (en) * | 2018-09-25 | 2020-04-02 | Heterocyclic Compound | Heterocyclic compound |
US11130752B2 (en) | 2018-09-25 | 2021-09-28 | Cardurion Pharmaceuticals, Llc | Aminopyrimidine compound |
GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
CN109364248B (zh) * | 2018-10-16 | 2021-05-18 | 哈尔滨医科大学 | ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用 |
AR116592A1 (es) | 2018-10-17 | 2021-05-26 | Lilly Co Eli | Tratamiento de la colangitis biliar primaria y la colangitis esclerosante primaria con baricitinib |
TWI820301B (zh) | 2019-02-15 | 2023-11-01 | 美商輝瑞股份有限公司 | 結晶型嘧啶基-3,8-二氮雜雙環〔3.2.1〕辛烷基甲酮化合物及其用途 |
CN111658628B (zh) * | 2019-03-08 | 2022-03-01 | 中国科学院动物研究所 | Gli2抑制剂的用途以及抑制gli2的化合物的筛选方法 |
JP7248256B2 (ja) | 2019-03-14 | 2023-03-29 | 上海華匯拓医薬科技有限公司 | Jakキナーゼ阻害剤及びその調製方法、並びにその医薬分野での使用 |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
JPWO2020203609A1 (en]) | 2019-03-29 | 2020-10-08 | ||
WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
EP3959213B1 (en) | 2019-04-24 | 2024-06-05 | Theravance Biopharma R&D IP, LLC | Pyrimidine jak inhibitors for the treatment of skin diseases |
JP7470713B2 (ja) * | 2019-04-24 | 2024-04-18 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | Jakキナーゼ阻害剤としてのエステルおよびカルボナートピリミジン化合物 |
CA3138473A1 (en) | 2019-04-30 | 2020-11-05 | Celgene Corporation | Combination therapies comprising apremilast and tyk2 inhibitors |
WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
EP3962894A4 (en) | 2019-05-02 | 2023-01-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND USES THEREOF |
JP2022543690A (ja) * | 2019-08-09 | 2022-10-13 | 中国医▲薬▼研究▲開▼▲発▼中心有限公司 | 架橋ヘテロシクリル置換ピリミジン化合物、その調製方法、及びその薬学的使用 |
CN114667148A (zh) * | 2019-09-11 | 2022-06-24 | 辉瑞公司 | 用jak抑制剂治疗汗腺炎 |
US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
CN110862376A (zh) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
CN110627775A (zh) * | 2019-10-24 | 2019-12-31 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN113372351A (zh) * | 2020-03-10 | 2021-09-10 | 明慧医药(杭州)有限公司 | 一类jak激酶抑制剂及其制备和应用 |
CN113372364B (zh) * | 2020-03-10 | 2024-05-31 | 明慧医药(上海)有限公司 | 一类jak激酶抑制剂及其制备和应用 |
EP4122922A4 (en) * | 2020-03-17 | 2023-08-23 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | CONDENSED BICYCLIC DERIVATIVE, METHOD OF MANUFACTURE THEREOF AND PHARMACEUTICAL USE THEREOF |
CN115715194A (zh) | 2020-04-04 | 2023-02-24 | 辉瑞公司 | 治疗冠状病毒疾病2019的方法 |
GB202005114D0 (en) | 2020-04-07 | 2020-05-20 | Sareum Ltd | Crystalline Forms of a Pharmaceutical Compound |
CN111423420A (zh) * | 2020-04-30 | 2020-07-17 | 广州博济医药生物技术股份有限公司 | 作为己酮糖激酶抑制剂的并环化合物 |
EP4149470A4 (en) | 2020-05-13 | 2024-04-24 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
CN113698403B (zh) * | 2020-05-21 | 2022-06-28 | 南京亘泰医药技术有限公司 | (1r,4r,7r)-7-氨基-2-氮杂双环[2,2,1]庚烷衍生物及制备方法 |
WO2021249367A1 (zh) * | 2020-06-09 | 2021-12-16 | 苏州晶云药物科技股份有限公司 | 二氮杂双环类化合物的对甲苯磺酸盐新晶型及其制备方法 |
TWI782599B (zh) * | 2020-07-02 | 2022-11-01 | 美商輝瑞股份有限公司 | 胺基嘧啶基衍生物 |
AR122756A1 (es) | 2020-07-02 | 2022-10-05 | Pfizer | Preparación de un derivado de pirimidinil-3,8-diazabiciclo[3.2.1]octanilmetanona y sal de este |
US20230277537A1 (en) | 2020-07-17 | 2023-09-07 | Pfizer Inc. | Stable pharmaceutical topical formulation containing immunosuppressant for treating dermatological condition |
MX2023002850A (es) | 2020-09-10 | 2023-07-07 | Precirix N V | Fragmento de anticuerpo contra proteina activadora de fibroblastos (fap). |
JP2024502601A (ja) * | 2021-01-07 | 2024-01-22 | バイオジェン・エムエイ・インコーポレイテッド | Tyk2阻害剤 |
CA3204761A1 (en) * | 2021-01-14 | 2022-07-21 | Huijun YIN | Bridged heterocyclyl-substituted pyrimidine compounds, preparation method and medical use thereof |
CN114835717A (zh) * | 2021-02-01 | 2022-08-02 | 杭州领业医药科技有限公司 | Brepocitinib甲苯磺酸盐的晶型及其制备方法和用途 |
MX2023009857A (es) | 2021-03-15 | 2024-01-03 | Maze Therapeutics Inc | Inhibidores de la glucogeno sintasa 1 (gys1) y metodos de uso de los mismos. |
CN113698409B (zh) * | 2021-08-10 | 2022-07-19 | 上海凌凯医药科技有限公司 | 一种多用途的二氮杂双环类化合物、制备方法及在合成药物中的应用 |
CN113999239B (zh) * | 2021-07-14 | 2022-11-11 | 上海凌富药物研究有限公司 | 一种二氮杂桥化合物的合成方法 |
CN113461687B (zh) * | 2021-08-10 | 2022-04-19 | 四川大学华西医院 | 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途 |
WO2023041061A1 (zh) * | 2021-09-17 | 2023-03-23 | 江苏恒瑞医药股份有限公司 | 一种稠合二环类衍生物的可药用盐、晶型及其制备方法 |
MX2024004993A (es) | 2021-10-25 | 2024-05-07 | Kymera Therapeutics Inc | Agentes degradantes de la proteina tirosina cinasa 2 (tyk2) y usos de los mismos. |
CN114181097B (zh) * | 2021-12-10 | 2024-05-14 | 广东嘉博制药有限公司 | 一种盐酸甲氧明的合成方法 |
JP2025509615A (ja) * | 2022-03-17 | 2025-04-11 | ファイザー・インコーポレイテッド | 汗腺炎を治療するための方法、投与計画、および組成物 |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
CN118005609B (zh) * | 2022-11-09 | 2025-06-17 | 沈阳药科大学 | 2-氨基嘧啶类化合物及其用途 |
WO2024148184A1 (en) * | 2023-01-04 | 2024-07-11 | Aerie Pharmaceuticals, Inc. | Compounds and processes for the preparation of jak inhibitors |
AU2024206079A1 (en) * | 2023-01-04 | 2025-07-10 | Alcon Inc. | Polymorphs of a jak1/tyk2 inhibitor and uses thereof |
TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ras相關疾病或病症之組合療法 |
CN116396298A (zh) * | 2023-06-06 | 2023-07-07 | 四川维亚本苑生物科技有限公司 | CDK Ligand-1的中间体XII及CDK Ligand-1的制备方法 |
CN116903592B (zh) * | 2023-07-13 | 2025-08-01 | 特科罗生物科技(成都)有限公司 | 一种嘧啶胺类nuak抑制剂及其制备方法和用途 |
WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
CN117756822B (zh) * | 2023-12-20 | 2025-04-18 | 英矽智能科技(上海)有限公司 | 作为jak抑制剂和phd抑制剂的嘧啶氨基类化合物 |
WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4131139A1 (de) | 1991-09-19 | 1993-03-25 | Bayer Ag | Verfahren zur herstellung von 1-fluor-cyclopropan-1-carbonsaeure |
US7381833B2 (en) | 2004-03-31 | 2008-06-03 | Daiichi Pharmaceutical Co., Ltd. | Process for producing 1,2-cis-2-fluorocyclopropane-1-carboxylic ester compound |
EP1867331A4 (en) | 2005-04-06 | 2009-04-08 | Takeda Pharmaceutical | TRIAZOLE DERIVATIVE AND USE THEREOF |
AU2006301435A1 (en) | 2005-10-13 | 2007-04-19 | Glaxo Group Limited | Pyrrolopyrimidine derivatives as Syk inhibitors |
NL2000323C2 (nl) * | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
TWI423976B (zh) * | 2006-01-17 | 2014-01-21 | Vertex Pharma | 適合作為傑納斯激酶(janus kinase)抑制劑之氮雜吲哚 |
WO2008032064A1 (en) * | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | Pyrimidine derivatives |
WO2008032033A1 (en) * | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
TW200904437A (en) * | 2007-02-14 | 2009-02-01 | Janssen Pharmaceutica Nv | 2-aminopyrimidine modulators of the histamine H4 receptor |
CN101679440A (zh) * | 2007-04-02 | 2010-03-24 | 帕劳制药股份有限公司 | 作为jak3抑制剂的吡咯并嘧啶衍生物 |
WO2009005675A1 (en) | 2007-06-28 | 2009-01-08 | Abbott Laboratories | Novel triazolopyridazines |
US8076491B2 (en) | 2007-08-21 | 2011-12-13 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
ES2439969T3 (es) | 2008-07-16 | 2014-01-27 | F. Hoffmann-La Roche Ag | Nuevos compuestos heterocíclicos para el tratamiento de enfermedades cardiovasculares |
WO2010075273A1 (en) * | 2008-12-23 | 2010-07-01 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
AR077465A1 (es) | 2009-07-08 | 2011-08-31 | Leo Pharma As | Derivados de pirrolopirimidina como inhibidores de receptores jak y protein tirosin quinasas y uso farmaceutico de los mismos |
US9040545B2 (en) | 2010-08-20 | 2015-05-26 | Cellzome Limited | Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors |
AU2012312305B2 (en) | 2011-09-22 | 2016-11-17 | Merck Sharp & Dohme Corp. | Acyclic cyanoethylpyrazoles as janus kinase inhibitors |
CN104220601A (zh) | 2011-12-16 | 2014-12-17 | 英威达技术有限责任公司 | 经与碳储存相关的CoA 依赖性碳链延长制备6 碳化学品的方法 |
NO2721710T3 (en]) | 2014-08-21 | 2018-03-31 | ||
HUE046057T2 (hu) | 2014-08-21 | 2020-02-28 | Boehringer Ingelheim Int | Új spiro[3H-indol-3,2'-pirrolidin]-2(1H)-on vegyületek és származékok, mint MDM2-P53-inhibitorok |
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